Formulasi Mikroemulsi Glukosamin Hidroklorida
Glucosamine Hydrochloride (Glucosamine HCl) is a compound that has been used as a supplement for reducing joint narrowing and pain in osteoarthritis patients. There are some factors which is still a challenge in glucosamine as a drug development : large dose to absorbed in a transdermal route and maillard product easily produced when glucosamine dissolved in water. This research aims to develop glucosamine HCl for skin application by enhancing the permeability toward stratum corneum and the stability of drug. Glucosamine HCl developed into O/W microemulsion where the optimum formula are : glucosamine hydrochloride 15%, isopropyl myristate 4,2%, Tween 80 22,7%, isopropyl alcohol 5,7%, sodium metabisulfite 0,1% and deionized water 52,3%. Characterization tests showed that this preparation meet the requirements of microemulsion such organoleptic, viscosity and globules size. Microemulsion showed their stability by centrifugation test and quantification test using HPLC obtained glucosamine hydrochloride 14,9%.
glucosamine hydrochloride; microemulsion; transdermal
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