OPTIMASI TITANIUM DIOKSIDA DAN ASAM GLIKOLAT DALAM KRIM TABIR SURYA KOMBINASI BENZOFENON-3 DAN OKTIL METOKSISINAMAT

Viddy Agustian Rosyidi, Wirawan Deni, Lidya Ameliana

Abstract


ABSTRAK

 

Sinar ultraviolet (UV) memiliki dampak buruk, yaitu sinar UV-A mampu menyebabkan pigmentasi dan sinar UV-B mampu menginduksi eritema, melanogenesis, kerusakan DNA, dan karsinoma sel skuamosa. Dampak buruk sinar UV terhadap kulit dapat diatasi dengan penggunaan tabir surya. Penelitian ini dilakukan penentuan formula optimum dari kombinasi titanium dioksida dan asam glikolat pada krim tabir surya terhadap beberapa respon, yaitu pH, viskositas, SPF, % transmisi eritema dan % transmisi pigmentasi dengan rancangan formula desain faktorial. Empat formula krim tabir surya telah dibuat dengan perbedaan pada proporsi titanium dioksida dan asam glikolat. Formula optimum yang terpilih adalah kombinasi titanium dioksida dan asam glikolat dengan proporsi 1% : 0,5% yang memberikan prediksi respon paling baik.

 

Kata kunci: titanium dioksida, asam glikolat, tabir surya, krim, benzofenon-3, oktil metoksisinamat

 

 

 

ABSTRACT

 

Ultraviolet (UV) ray has bad effects on the skin, i.e. UV-A induced pigmentation and UVB induced erythema, melanogenesis, DNA damage, and squamous cell carcinoma. These bad effects can be prevented by using sunscreen. The aims of this study were to optimize titanium dioxide and glycolic acid on sunscreen cream formula according to observed pH, viscosity, SPF, % of erythema transmission and % of pigmentation transmission using factorial design. Four sunscreen cream formulas had different ratio of titanium dioxide and glycolic acid were observed. The optimum formula was combination of titanium dioxide and glycolic acid with  1% : 0,5% ratio; which gave the best predicted responses.

 

Key words: titanium dioxide, glycolic acid, sunscreen, cream, benzophenone-3, octyl methoxycinnamate



Keywords


titanium dioksida; asam glikolat; tabir surya; krim; benzofenon-3; oktil metoksisinamat

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DOI: 10.30595/pharmacy.v15i1.2567

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ISSN: 2579-910X