Synthesis of Curcumin Derivative Assisted by Microwave Irradiation
Synthesis of curcumin derivate is commonly conducted using conventional heating like heating mantel. The synthesis was usually done in the very long time. An experiment on finding an efficient synthesis method may be necessary to conduct, such as using microwave to replace the energy source. The synthesis of curcumin derivate 1,5-bis(4’-hydroxy-3’-metoxyphenyl)-1,4-pentadiene-3-one or gamavuton-0 assisted by microwave irradiation has been carried out. This synthesis was done on propose of cancer drug discovery to answer the search of new cancer drug on the increase of cancer incidence recently. The synthesis was done under microwave irradiation using vanillin and acetone as the starting material, and hydrochloric acid as the catalyst. Based on the experimental data, the microwave irradiation significantly reduces the reaction time. By using microwave irradiation, the synthesis can be done in a short time.
Agrawal, D.K., Mishra, P.K. 2010, Curcumin and its analogues: potential anticancer agents. Medicinal research reviews, 30(5):818-860.
De la Hoz, A., Dı ´az-Ortiz, A., and Moreno, A. 2005. Microwaves in organic synthesis. Thermal and non-thermal microwave effects. Chemical Social Review, 34:164–178.
Fahrurozi. 2008. Pengaruh jumlah mol pereaksi pada sintesis senyawa GVT-0 dengan pelarut etanol dan uji sitotoksiknya terhadap sel Hela). Skripsi. Faculty of Phamacy, Universitas Gadjah Mada, Yogyakarta.
Fessenden, R.J. and Fessenden, J.S. 1999. Organic Chemistry. Part 2. Edited by A.H. Pudjaatmaka. Jakarta: Erlangga Press.
Handayani, S., Budimarwanti, C., and Haryadi, W. 2017. Microwave-assisted organic reactions: eco-friendly synthesis of dibenzylidenecyclohexanone derivatives via crossed aldol condensation. Indonesian Journal of Chemistry. 17(2):336–341.
Harimurti, S., Widada, H., Kadarinah, S., Hadi, I., Wijaya, D.P., Komarudin, and Rifai, M.A. 2017. Optimization of anti-cancer gamavuton-0 synthesis using box behnken experimental design. Advanced Science Letters, 23:12498–12501.
Hughes, J.P., Rees, S., Kalindjian, S.B., and Philpott, K.L. 2011. Review: principles of early drug discovery. British Journal of Pharmacology, 162:1239–1249.
Nugroho, A. 2009. Sintesa 2-5-bis(4‘-hidroksi-3‘-metoksibenzilidin) siklopentanon dengan variasi suhu 28 oC, 38 oC, 48 oC pada fase pengadukan. Skripsi. Faculty of Pharmacy, Gadjah Mada University, Yogyakarta.
Ravichandran, S. and Karthikeyan, E. 2011. Microwave synthesis - a potential tool for green chemistry. International Journal of ChemTech Research, 3(1):466-470.
Sardjiman. 2000. Synthesis of some new series of curcumin analogues, antioxidative, antiinflammatory, antibacterial activities and quantitative structure activity relationship Dissertation, Gadjah Mada University, Yogyakarta.
Veronesi, P., Leonelli, C., and Bondioli, F. 2017. Energy efficiency in the microwave-assisted solid-state synthesis of cobalt aluminate pigment. Technologies, 5(42):1-13.
Wanninger, S., Lorenz, V., Subhan, A., and Edelmann, F.T. 2015. Metal complexes of curcumin– synthetic strategies, structures and medicinal applications. Chemical Social Review, 44:4986–5002.
Yuniarti, N. 2006. Aktivitas antiinflamasi invivo dan invitro 1,5-bis(4’-hidroksi-3’-etoksifenil)-1,4-pentadien-3-on indometasin dan turunannya. Thesis. Universitas Gadjah Mada, Yogyakarta.
This work is licensed under a Creative Commons Attribution 4.0 International License.