Formulasi dan Uji Sifat Fisik Sediaan Nanoemulsi Natrium Diklofenak dengan Kombinasi Tween 80 dan Transkutol
DOI:
https://doi.org/10.30595/sainteks.v17i1.6896Abstract
Natrium diklofenak digunakan untuk nyeri dapat diberikan peroral, intramuskular dan suppositoria. Tetapi menyebabkan nyeri, iritasi lokal, dan kerusakan jaringan pada tempat injeksi. Nanoemulsi dikembangkan untuk meningkatkan bioavailabilitas obat dalam tubuh. Nanoemulsi dibuat dengan mengkombinasikan fase minyak, fase air, surfaktan dan kosurfaktan. Fase minyak virgin coconut oil (VCO) dan kombinasi Tween 80 dan Transkutol sebagai surfaktan dan kosurfaktan dapat meningkatkan absorpsi perkutan melewati barrier kulit dan mukosal. Penelitian ini bertujuan untuk mengetahui formula terbaik untuk sediaan nanoemulsi natrium diklofenak dengan variasi konsentrasi Tween 80 dan Transkutol dan mengetahui pengaruh penambahan Transkutol sebagai kosurfaktan dalam sediaan nanoemulsi natrium diklofenak. Nanoemulsi dibuat dengan metode emulsifikasi spontan. Perbandingan surfaktan dengan kosurfaktan pada formula yang digunakan yaitu Formula 1 (5:1), Formula 2 (6:1), Formual 3 (7:1), dan Formula 4 (1:0). Hasil ukuran globul nanoemulsi Formula 1 10,9 nm; Formula 2 11,7 nm; Formula 3 7,1 nm; Formula 4 8,8 nm. Zeta potensial Formula 1 -57,3 mV, Formula 2 -63,0 mV, Formula 3 -50,1 mV, Formula 4 -27,6 mV. Hasil pH Formula 1 7,4 ± 0,032; Formula 2 7,4 ± 0,015; Formula 3 7,4 ± 0,021; Formula 4 7,7 ± 0,046. Hasil viskositas Formula 1 642,67±7,64 cP; Formula 2 662,67±7,64 cP; Formula 3 715,00±10,00 cP; Formula 4 864,33±7,09 cP. Hasil sentrifugasi pada semua formula tidak mengalami pemisahan fase. Hasil dari semua uji menunjukkan Formula 1 merupakan formula terbaik dalam penampilan dan sifat fisik yang diuji.
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