Vasodilation Effects of Ketapang (<i>Terminalia catappa</i> Linn) Fruit on Aortic Rings Rat

Authors

  • Joseffine Valentina Wijaya Mulawarman University
  • Sjarif Ismail Mulawarman University
  • Siti Khotimah Mulawarman University

DOI:

https://doi.org/10.30595/hmj.v7i1.21626

Keywords:

Terminalia catappa, fruit, vasodilation, aortic ring, bioassay.

Abstract

Hypertension is an important risk factor for cardiovascular disease. Hypertension requires long-term treatment to keep blood pressure under control. Exploration found that antihypertensive drugs have economic value. East Kalimantan is rich in medicinal plant diversity and needs to be explored to discover new drugs for hypertension. Ketapang fruit (Terminalia catappa Linn) has the potential to have a vasodilation effect so research is needed to explore vasodilation activity in vitro. This research to determine the vasodilation activity of Terminalia catappa fruit using isolated aortic ring bioassay. Twelve Wistar rats were used for bioassays isolated aortic ring with endothelium.  The aortic rings is precontracted with phenylephrine. This study used two test groups, Control group and Terminalia catappa fruit ethanol extract group (FTC). The FTC and Control concentrations were given cumulatively in chamber of isolated aortic ring. Log concentration -2 FTC (-11.8 ± 3.5)% and Control (0.0 ± 0.0)%, p = 0,002; log concentration -1,5 FTC (-22.8 ± 2.5)% and Control (0.0 ± 0.0)%, p = 0,002; log concentration -1,0 FTC (-41.5 ± 2.8)% and Control (0.0 ± 0.0)%, p = 0,002; log concentration -0,5 FTC (-58.7 ± 3.1)% and Control (0.0 ± 0.0)%, p = 0,002; log concentration 0 FTC (-79.0 ± 3.4)% and Control (0.0 ± -1.9)%, p = 0,001; log concentration 0,5 FTC (-93.8 ± 3.0)% and Control (0.2 ± 1.5)%, p = 0,002. FTC causes vasodilation in isolated rat aortic rings with endothelium.

Author Biography

Joseffine Valentina Wijaya, Mulawarman University

Mulawarman University

References

1. Sherwood L. Human Physiology From Cells to Systems. 9th ed. Vol. 6. 2016.

2. Saadah S. Sistem Peredaran Darah Manusia. 2018. 1–58 p.

3. Klabunde RE. Cardiovascular Physiology Concepts. 2nd ed. Philadelphia: Wolters Kluwer; 2012. 243 p.

4. Kosasih A, Lukito AA, Soenarta AA, Tiksnadi A, Kuncoro AS, Anantaria C. Konsensus Penatalaksanaan Hipertensi 2019. Indonesian Society Hipertensi Indonesia. 2019. 1–90 p.

5. Regulski M os., Regulska K, Stanisz B, Murias M, Gieremek P, Wzgarda A, et al. Chemistry and Pharmacology of Angiotensin-Converting Enzyme Inhibitors. Curr Pharm Des. 2014;21(13):1764–75.

6. Widiastuti TC, Khuluq H, Handayani EW, Wulandari AS, Hemas E, Kurniawan I, et al. Pemanfaatan Tanaman Obat untuk Mengatasi Penyakit Diabetes Melitus di Kota Kebumen. J Farm Klin dan Sains. 2022;2(1):87–96.

7. Khan AU, Gilani AH. Pharmacodynamic Evaluation of Terminalia bellerica for Its Antihypertensive Effect. J Food Drug Anal. 2008;16(3):6–14.

8. Akbari G. Molecular Mechanisms Underlying Gallic Acid Effects Against Cardiovascular Diseases: An Update Review. Avicenna J Phytomedicine. 2020;10(1):11–23.

9. Marjenah, Ariyanto. Tanaman Ketapang (Terminalia catappa Linn.) pada Beberapa Sistem Lahan di Kalimantan Timur dan Prosfeknya sebagai Hutan Tanaman dengan Model Agroforestri. J Penelit Ekosist Dipterokarpa. 2018;4(2):57–70.

10. Dewi P, Putri AR, Bintari SH, Mubarok I. Uji Efektivitas Ekstrak Buah Ketapang (Terminalia catappa) terhadap Bakteri Escherichia coli dan Bacillus subtilis. Life Sci [Internet]. 2022;11(1):47–59. Available from: http://journal.unnes.ac.id/sju/index.php/LifeSci

11. Tew WY, Tan CS, Yan CS, Loh HW, Wen X, Wei X, et al. Evaluation of Vasodilatory Effect and Antihypertensive Effect of Chrysin Through In Vitro and Sub-chronic In Vivo Study. Biomed Pharmacother. 2023;157.

12. Kosala K, Ismail S, Fikriah I, Magdaleni AR. In Vitro Exploration of Vasodilation Activity of the Methanol Extract of the Coptosapelta flavescens Korth Stem. 2017;1(2):10–4.

13. Fikriah I, Ismail S, Kosala K. In Vitro Evaluation of the Vasodilatory Activity of Ethanol Extracts of Eleutherine bulbosa Bulbs and Leaves. J Appl Pharm Sci. 2021;11(5):135–40.

14. Ismail S, Yuniati. Aktivitas Vasodilatasi Pembuluh Darah secara in vitro dan Uji Toksisitas Akut Minuman Fungsional Herbal Kaltim. J Trop Pharm Chem. 2016;3(3):197–201.

15. Hakim AR, Saputri R. Narrative Review: Optimasi Etanol sebagai Pelarut Senyawa Flavonoid dan Fenolik. J Surya Med. 2020;6(1):177–80.

16. Permatasari A, Batubara I, Nursid M. Pengaruh Konsentrasi Etanol dan Waktu Maserasi terhadap Rendemen, Kadar Total Fenol dan Aktivitas Antioksidan Ekstrak Rumput Laut Padina australis. A Sci J. 2020;37(2):78–84.

17. Kurniawidjaja LM, Lestari F, Tejamaya M, Ramdhan DH. Konsep Dasar Toksikologi Industri. Fkm Ui. 2021. 54–73 p.

18. Tortora, GJ & Derrickson B. Tortora, GJ & Derrickson, B. 2014. 1–23 p.

19. Saputra DR, Imansari IP, Elnisa AR, Amania HN, Gigi FK, Jember U, et al. Penggunaan Vasokonstriktor dalam Anestesi Lokal Kedokteran Gigi pada Pasien Kompromis Medis: Telaah Pustaka. Stomatognatic (JKG Unej). 2023;20(1):56–62.

20. Mahajan H, Kolka CM, Newman JMB, Rattigan S, Richards SM, Clark MG. Vascular and Metabolic Effects of Methacholine in Relation to Insulin Action in Muscle. Diabetologia. 2006;49(4):713–23.

21. Hajiluian G, Karegar SJ, Shidfar F, Aryaeian N, Salehi M, Lotfi T, et al. The Effects of Ellagic acid Supplementation on Neurotrophic, Inflammation, and Oxidative Stress Factors, and Indoleamine 2, 3-Dioxygenase Gene Expression in Multiple Sclerosis Patients with Mild to Moderate Depressive Symptoms: A Randomized, Triple-blind,. Phytomedicine. 2023;121:155094.

22. Perumal V, Khatib A, Uddin Ahmed Q, Fathamah Uzir B, Abas F, Murugesu S, et al. Antioxidants Profile of Momordica charantia Fruit Extract Analyzed Using LC-MS-QTOF-Based Metabolomics. Food Chem Mol Sci. 2021;2:4–11.

23. Wang B, Tang X, Mao B, Zhang Q, Tian F, Zhao J, et al. Effects of in vitro Fecal Fermentation on the Metabolism and Antioxidant Properties of Cyanidin-3-O-Glucoside. Food Chem. 2023;431:1–5.

24. da Silva FB, Romero WG, Rouver W do N, Silva K, de Almeida SA, Mengal V, et al. Ellagic Acid Prevents Vascular Dysfunction in Small Mesenteric Arteries of Ovariectomized Hypertensive Rats. J Nutr Biochem. 2022;105(July):2–6.

25. Li W, Chen H, Xu B, Wang Y, Zhang C, Cao Y, et al. Research Progress on Classification, Sources and Functions of Dietary Polyphenols for Prevention and Treatment of Chronic Diseases. J Futur Foods [Internet]. 2023;3(4):289–305. Available from: https://doi.org/10.1016/j.jfutfo.2023.03.001

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Published

2024-04-30

Issue

Vol. 7 No. 1 (2024): Herb-Medicine Journal April 2024

Section

Research Articles

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