Pengaruh Buah Sirsak Terhadap Faktor Risiko Kardiovaskular (Kolesterol Total, HDL, LDL, Trigliserida)
DOI:
https://doi.org/10.30595/hmj.v4i2.6805Keywords:
soursop, cardiovaskular, total cholesterol, HDL, LDL, triglyserideAbstract
Soursop fruit contains phenolic, tannins, flavonoids. Phenolic inhibit xanthine oxidase inhibitors which inhibit the production of uric acid, this will affect in decreasing cardiovascular risk. Tannins reducing triglyceride levels. Flavonoids reduce HMG-CoA reductase and total cholesterol. Several studies conducted on animal experiments and the results of soursop fruit reduce lipid profile. What is the effect of soursop fruit consumption on cardiovascular risk in healthy humans? This epidemiological research was conducted in Mlati, Sleman, Indonesia. There were 143 subjects that conform to the inclusion and exclusion criteria subsequently randomized to two groups. Group I was given 2x100 g/day of soursop and group II was without soursop. A laboratory examination was conducted of total cholesterol, HDL, LDL, and triglyceride levels at weeks 0, 7, and 13 both in the soursop and non-soursop groups. Regular soursop consumption was evaluated every two weeks for three months. Data analysis was performed using an independent t test, a nonparametric Mann–Whitney test, and a chi-square test. There was no significant difference in total cholesterol (p=0.254 and p=0.932), HDL (p=0.400 and p=0.960), LDL (p=0.221 and p=0.710), triglycerides (p=0.423 and p=0.580) between the soursop and non-soursop groups. The consumption of soursop fruit at 2x100 g/day has no significant effect on improvement in cardiovascular risk (total cholesterol, HDL, LDL, triglycerides) in healthy subjects, but in subjects with hypercholesterolemia and hypertriglyceridemia, the mean cholesterol and triglyceride levels decreased at week 7 and 13 compared to no soursop consumptionReferences
1. Cheong KW, Tan CP, Mirhosseini H, Chin ST, Che Man YB, Hamid NSA, et al. Optimization of equilibrium headspace analysis of volatile flavor compounds of malaysian soursop (Annona muricata): Comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOFMS). Food Chemistry. 2011;125(4):1481–9. Available from: http://www.sciencedirect.com/science/article/pii/S0308814610013245
2. Sobrinho RB, Bandeira CT, Mesquita ALM. Occurrence and damage of soursop pests in northeast Brazil. Crop Protection. 1999;18(8):539–41. Available from: http://www.sciencedirect.com/science/article/pii/S0261219499000514
3. Kim G-S, Zeng L, Alali F, Rogers LL, Wu F-E, Sastrodihardjo S, et al. Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of annona muricata in honour of professor G. H. Neil Towers 75th birthday. Phytochemistry. 1998;49(2):565–71. Available from: http://www.sciencedirect.com/science/article/pii/S0031942298001721
4. Adeyemi DO, Komolafe OA, Adewole SO, Obuotor EM, Adenowo TK. Effects Of Annona Muricata (Linn) On The Morphology Of Pancreatic Islet Cells Of Experimentally-Induced Diabetic Wistar Rats. The Internet Journal of Alternative Medicine. 2007;5(2):8. Available from: https://www.semanticscholar.org/paper/Effects-Of-Annona-Muricata-(Linn)-On-The-Morphology-Adeyemi-Komolafe/1d4382cadf6f832a02c8276d935ba8a55086c0f3
5. Coria-Téllez AV, Montalvo-Gónzalez E, Yahia EM, Obledo-Vázquez EN. Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arab J Chem. 2016; Available from: http://www.sciencedirect.com/science/article/pii/S1878535216000058
6. Tia HD, Sistiyono S, Hendarta NY. Pengaruh Berbagai Dosis Jus Buah Sirsak (Annona muricata L.) Terhadap Penurunan Kadar Kolesterol Low Density Lipoprotein (LDL) Serum Tikus Putih (Rattus norvegicus) Dislipidemia. Jurnal Teknologi Laboratorium. 2014;3(2):84–90. Available from: https://www.teknolabjournal.com/index.php/Jtl/article/view/65
7. Tugiyanti E, Heriyanto S, Syamsi AN. Pengaruh Tepung Daun Sirsak (Announa Muricata L) terhadap Karakteristik Lemak Darah dan Daging Itik Tegal Jantan. Buletin Peternakan. 2016;40(3):211. Available from: https://journal.ugm.ac.id/buletinpeternakan/article/view/11243
8. de la Cruz AMA, Catabay AP. Hypolipidemic Effect of the Lyophilized Fruit Pulp of Guyabano, Annona Muricata Linn. (Fam. Annonaceae) in Atherogenic Diet-Induced Hyperlipidemia in Albino Rats. JAASP. 2016;1:351–9. Available from: http://www.aaspjournal.org/abstractinfo.php?id=74
9. Sasso S, Sampaio e Souza PC, Santana LF, Cardoso CAL, Alves FM, Portugal LC, et al. Use of an Extract of Annona muricata Linn to Prevent High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice. Nutrients. 2019;11(7). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682994/
10. Ewadh MJ, Smaism MF, Jawad AM, Mkhlof S, Aljubouri OM, Ewadh MM. Using Soursop Extracts for Natural Gout Treatment. J Biosci Bioeng. 2015;3(5):37. Available from: http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=217&doi=10.11648/j.bio.20150305.12
11. Onyechi AU, Ibeanu VN, Eme PE, Kelechi M. Nutrient, Phytochemical Composition and Consumption Pattern of Soursop (Annona muricata) Pulp and Drink among Workers in University of Nigeria, Nsukka Community. Pakistan Journal of Nutrition. 2015;14(12):866–70. Available from: https://scialert.net/abstract/?doi=pjn.2015.866.870
12. Yokozawa T, Chung HY, He LQ, Oura H. Effectiveness of Green Tea Tannin on Rats with Chronic Renal Failure. Biosci Biotechnol Biochem. 1996;60(6):1000–5. Available from: https://www.jstage.jst.go.jp/article/bbb1992/60/6/60_6_1000/_article
13. Wurdianing I, Nugraheni SA, Rahfiludin Z. Efek Ekstrak Daun Sirsak (Annona Muricata Linn) Terhadap Profil Lipid Tikus Putih Jantan (Rattus Norvegicus). JGI. 2014;3(1):7–12. Available from: https://www.neliti.com/publications/79681/efek-ekstrak-daun-sirsak-annona-muricata-linn-terhadap-profil-lipid-tikus-putih
Downloads
Published
Issue
Section
License
For submission of manuscripts to the Herb-Medicine Journal, the authors must certify that:
I have been authorized by my co-author to submit the manuscript to the Herb-Medicine Journal
I hereby declare, on behalf of myself and my co-authors, that:
The submitted manuscript is original work and has not been published in another peer-reviewed journal or is being considered for publication by another journal. Also, the manuscript does not infringe any existing copyright or other third party rights.
The manuscript does not contain material that may violate the law, slander, or SARA, in any way, violates the terms and conditions contained in the agreement
I/we have taken care that the scientific knowledge and all other statements contained in the manuscript are in accordance with authentic facts and formulas and will not, if followed appropriately, harm the user
No liability shall be assumed by Herb-Medicine Journal, its staff or members of the editorial board for any injury and/or damage to persons or property as a matter of product liability, negligence or otherwise, or from the use or operation of any method, product instructions, advertising , or ideas contained in publications by the Herb-Medicine Journal
Authors who publish in the Herb-Medicine Journal certify that all authors have read and agree to the contents of the Cover Letter or the Terms and Conditions. Plagiarism is strictly prohibited, and by submitting a manuscript for publication, the author agrees that the publisher has the legal right to take appropriate action against the author, if plagiarism or false information is found. Once submitted to the Herb-Medicine Journal, authors will not withdraw their manuscript at any stage prior to publication.
The author owns the copyright and grants the journal rights for first publication with the work simultaneously licensed under a Creative Commons Attribution License which allows others to share the work with acknowledgment of the work's authorship and initial publication in this journal.
Authors may enter into separate additional contractual agreements for the non-exclusive distribution of the published journal version of the work (for example, posting it to an institutional repository or publishing it in a book), with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (for example, in institutional repositories or on their websites) prior to and during the submission process, as this can lead to productive exchanges, as well as earlier and larger citation of published work (See The Effects of Open Access).
Untuk pengiriman naskah ke Herb-Medicine Journal, penulis harus menyatakan bahwa:
- Saya telah diberikan otorisasi oleh rekan penulis saya untuk memasukkan naskah ke Herb-Medicine Journal
- Saya dengan ini menyatakan, atas nama saya dan rekan penulis saya, bahwa:
- Naskah yang dikirimkan adalah karya asli dan belum pernah diterbitkan dalam jurnal peer-review lain atau sedang dipertimbangkan untuk diterbitkan oleh jurnal lain. Serta, naskah tidak melanggar hak cipta yang ada atau hak pihak ketiga lainnya.
- Naskah tidak mengandung materi yang mungkin melanggar hukum, memfitnah, atau SARA, dengan cara apa pun, melanggar syarat dan ketentuan yang tercantum dalam perjanjian
- Saya / kami telah berhati-hati bahwa pengetahuan ilmiah dan semua pernyataan lain yang terkandung dalam naskah sesuai dengan fakta dan formula otentik dan tidak akan, jika diikuti dengan tepat, merugikan pengguna
- Tidak ada tanggung jawab yang ditanggung oleh Herb-Medicine Journal, stafnya atau anggota dewan editorial untuk setiap cedera dan/atau kerusakan pada orang atau properti sebagai masalah pertanggungjawaban produk, kelalaian atau sebaliknya, atau dari penggunaan atau pengoperasian metode, produk apa pun instruksi, iklan, atau ide yang terkandung dalam publikasi oleh Herb-Medicine Journal
Penulis yang menerbitkan dalam Herb-Medicine Journal menyatakan bahwa semua penulis telah membaca dan menyetujui isi Surat Pengantar atau Syarat dan Ketentuan. Plagiarisme dilarang keras, dan dengan menyerahkan naskah untuk publikasi, penulis setuju bahwa penerbit memiliki hak hukum untuk mengambil tindakan yang pantas terhadap penulis, jika ditemukan plagiarisme atau informasi palsu. Setelah diserahkan ke Herb-Medicine Journal, penulis tidak akan menarik naskah mereka pada tahap apa pun sebelum dipublikasikan.
Penulis memiliki hak cipta dan memberikan hak jurnal untuk publikasi pertama dengan karya yang secara simultan dilisensikan di bawah Lisensi Creative Commons Attribution yang memungkinkan orang lain untuk berbagi karya dengan pengakuan kepengarangan karya dan publikasi awal dalam jurnal ini.
Penulis dapat membuat perjanjian kontrak tambahan yang terpisah untuk distribusi non-eksklusif versi jurnal yang diterbitkan dari karya tersebut (misalnya, mempostingnya ke repositori institusional atau menerbitkannya dalam sebuah buku), dengan pengakuan atas publikasi awalnya di jurnal ini.
Penulis diizinkan dan didorong untuk memposting pekerjaan mereka secara online (misalnya, dalam repositori institusional atau di situs web mereka) sebelum dan selama proses pengajuan, karena dapat menyebabkan pertukaran yang produktif, serta kutipan yang lebih awal dan lebih besar dari karya yang diterbitkan (Lihat The Effect of Open Access).
