Evaluasi Uji Iritasi Dan Uji Sifat Fisik Pada Sediaan Krim M/A Minyak Atsiri Bunga Cengkeh Dengan Berbagai Variasi Konsentrasi

Authors

  • Aina Fatkhil Haque Program Pasca Sarjana Farmasi, Universitas Ahmad Dahlan, Jl. Prof. Dr. Soepomo, S.H., Janturan, Warbonnet, Umbulharjo, Yogyakarta, 55166, Indonesia
  • Nining Sugihartini Program Pasca Sarjana Farmasi, Universitas Ahmad Dahlan, Jl. Prof. Dr. Soepomo, S.H., Janturan, Warbonnet, Umbulharjo, Yogyakarta, 55166, Indonesia

Abstract

ABSTRAK Minyak atsiri cengkeh dengan bahan eugenol aktif telah terbukti secara ilmiah berkhasiat sebagai anti-inflamasi, sehingga diperlukan penelitian lebih lanjut terkait dengan formulasinya. Salah satu faktor penting dalam pengembangan formulasi adalah penentuan konsentrasi minyak atsiri dalam sediaan yang dimaksud. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas anti-inflamasi dari krim M/A yang mengandung minyak atsiri cengkeh dengan variasi konsentrasi. Metode yang digunakan dalam penelitian ini antara lain distilasi untuk proses ekstraksi minyak atsiri cengkeh dengan Kromatografi Gas Spektroskopi Massa (KGSM) untuk identifikasi senyawa aktif eugenol dalam minyak esensial cengkeh. Krim M/A minyak atsiri cengkeh dibuat dengan metode peleburan. Sifat fisik persiapan dievaluasi dengan menguji dispersi kekuasaan, adhesi, dan pH. Evaluasi efikasi dilakukan dengan menggunakan uji iritasi pada marmut dengan menggunakan metode Remington. Kata kunci: anti-inflamasi, minyak atsiri cengkih, krim M/A, sifat fisik. ABSTRACT Clove essential oil with the active ingredient eugenol has been scientifically proven efficacious as anti-inflammatory that further research related to the formulation continues. An important factor in the development of formulations is the determination of essential oil concentration. The purpose of this study was to determine the anti-inflammatory activity of O/W cream contain clove essential oils with varying concentrations. The method used in this study includes the extraction process of clove essential oil with distillation method and identification of the active compound eugenol in clove essential oil with Gas Chromatography Mass Spectroscopy (GCMS). Preparation of a O/W cream was performed by the method of smelting. Physical properties of the preparation are evaluated by testing the dispersive power, adhesion, and pH. Evaluation of efficacy was done by using the irritating test on guinea pigs used Remington method. Key words: anti-inflammatory, clove essential oil, O/W cream, physical properties.

References

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Published

2015-12-01

How to Cite

Haque, A. F., & Sugihartini, N. (2015). Evaluasi Uji Iritasi Dan Uji Sifat Fisik Pada Sediaan Krim M/A Minyak Atsiri Bunga Cengkeh Dengan Berbagai Variasi Konsentrasi. PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 12(2), 131–139. Retrieved from http://jurnalnasional.ump.ac.id/index.php/PHARMACY/article/view/325

Issue

Jurnal Pharmacy, Vol. 12 No. 02 Desember 2015

Section

PHARMACY

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