Uji Aktivitas Analgesik Minyak Ikan pada Mencit Putih (Mus musculus) Jantan Galur BALB/c dengan Metode Writhing Test
DOI:
https://doi.org/10.30595/pharmacy.v17i1.5049Keywords:
analgesik, asetosal, laut, minyak ikan salmon, nutrasetikalAbstract
Minyak ikan merupakan sumber EPA dan DHA yang berasal dari sumber daya laut. Kapsul minyak ikan merupakan salah satu nutraseutikal untuk memenuhi kebutuhan omega-3 dan omega-6. Penelitian telah dilakukan menggunakan minyak ikan salmon yang mengandung EPA dan DHA. Tujuan dari penelitian ini adalah untuk menentukan aktivitas analgesik pada tikus putih jantan (Mus musculus) strain BALB/c. Sejumlah 25 ekor tikus putih jantan dibagi menjadi 5 kelompok, masing-masing kelompok terdiri dari 5 ekor tikus putih jantan. Kelompok kontrol negatif diberi kombinasi emulsi Tween 80 dan Span 80, kelompok kontrol positif diberi aspirin, dan kelompok perlakuan diberi emulsi minyak ikan salmon dengan dosis 20, 30, dan 40 mg/kg BB. Metode yang digunakan pada penelitian ini adalah writhing test dengan menginduksi tikus putih jantan dengan asam asetat 0,6%. Hasil penelitian menunjukkan bahwa emulsi minyak ikan salmon dengan dosis 20, 30, dan 40 mg/kg BB memiliki persentase hambatan nyeri masing-masing sebesar 29,44; 42,64; dan 52,59%. Dapat disimpulkan bahwa emulsi minyak ikan salmon memiliki aktivitas analgesik. Â
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