Formulasi Mikroemulsi Glukosamin Hidroklorida
Keywords:
glucosamine hydrochloride, microemulsion, transdermalAbstract
Glukosamin hidroklorida (glukosamin HCl) merupakan senyawa yang sudah populer sebagai suplemen untuk mengurangi rasa nyeri dan kerusakan sendi pada penderita osteoarthritis. Namun terdapat beberapa faktor yang menjadi tantangan dalam pengembangan sediaan glukosamin, yaitu dosis yang besar untuk diabsorpsi secara perkutan serta masalah stabilitas glukosamin di dalam air yang mudah sekali membentuk maillard product. Penelitian ini bertujuan untuk mengembangkan mikroemulsi glukosamin HCl untuk penggunaan transdermal sehingga permeabilitas terhadap stratum korneum meningkat dan stabilitas sediaan lebih baik. Dalam penelitian ini glukosamin HCl dikembangkan dalam bentuk mikroemulsi M/A dan diperoleh formula optimum dengan komposisi glukosamin HCl 15%, isopropil miristat 4,2%, Tween 80 22,70%, isopropil alkohol 5,70%, natrium metabisulfit 0,10%, aquadeion 52,30%. Uji karakterisasi menunjukkan mikroemulsi memenuhi persyaratan secara organoleptis, viskositas, serta ukuran globul. Mikroemulsi stabil pada uji sentrifugasi. Sementara uji kadar dengan menggunakan metode KCKT diperoleh hasil 14,9%.
References
Altman, R.D. 2009. Glucosamine therapy for knee osteoarthritis: pharmacokinetic considerations. expert. Rev. Clin. Pharmacol., 2(4):359-371.
Engelbrecht, T.N., Demé, B., Neubert, R.H. 2012. Study of the influence of the penetration enhancer isopropyl myristate on the nanostructure of stratum corneum lipid model membranes using neutron diffraction and deuterium labelling. Skin Pharmacol. Physiol., 25:200-207.
Han, I.H., Choi, S., Nam, D.Y., Park, Y.M., Kang, M.J., Kang, K.H., Kim, Y.M., Bae, G., Young, I., Park, J.H., Ye, J.S., Choi, Y.B., Kim, D.K., Lee, J., Choi, Y.W. 2010. Identification and assessment of permeability enhancing vehicles for transdermal delivery of glucosamine hydrochloride. Arch. Pharm. Res., 33(2):293-299.
Kanwischer, M., Kim, S.Y., Kim, J.S., Bian, S., Kwon, K.A., Kim, D.D. 2005. Evaluation of the physicochemical stability and skin permeation of glucosamine sulfate. Drug Dev. Ind. Pharm., 31:91-97.
Lehninger. 1995. Dasar – Dasar Biokimia. Cetakan keempat. Jakarta: Erlangga.
Marina, A.M., Che Man, Y.B., Hamid, N., Ismail, A. 2009. Chemical properties of virgin coconut oil. J. Am. Oil Chem. Soc., 86:301-307.
Reginster, J.Y., Deroisy, R., Rovati, L.C., Lee, R.L., Lejeune, E., Bruyere, O., Giarovelli, G., Henrotin, Y., Dacre, J.E., Gossette, C. 2001. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet, 357:251-256.
Rowe, R.C., Sheskey, P.J., Quinn, M.E. 2009. Handbook of Pharmaceutical Excipients. Sixth Edition. London: Pharmaceutical Press.
Tjahjono, D.H., Surantaatmadja, S., dan Darijanto, S.T. 2007. Analysis of glucosamine in cream dosage form and diffusion liquid by high performance liquid chromatography. J. Ion Exch., 18(4):420-421.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
