FORMULASI TABLET EKSTRAK ETANOL BUAH MENGKUDU (Morinda citrifolia L) DENGAN VARIASI AVICEL PH 101 DAN AMPROTAB SEBAGAI BAHAN PENGERING
DOI:
https://doi.org/10.30595/pji.v7i1.537Abstract
ABSTRAK Tanaman Mengkudu (Morinda citrifolia L) merupakan tanaman yang telah banyak digunakan sebagai obat tradisional oleh masyarakat. Agar penggunaan tanaman ini menjadi lebih praktis, perlu pengolahan menjadi bentuk sediaan yang mudah digunakan, salah satunya dalam bentuk sediaan tablet. Tujuan penelitian ini adalah untuk mengetahui apakah kombinasi bahan pengering Avicel PH 101 dan Amprotab dapat diformulasikan menjadi sediaan tablet ekstrak etanol buah mengkudu yang memenuhi syarat sifat fisik tablet. Ekstrak etanol buah mengkudu dibuat dengan menggunakan metode maserasi. Sedangkan tablet ekstrak etanol buah mengkudu dibuat dengan cara metode granulasi basah. Tablet ekstrak etanol buah mengkudu dibuat dalam tiga formula, yaitu formula I (100 % Avicel PH 101), formula II (100 % Amprotab) dan formula III (50 % Avicel PH 101 : 50 % Amprotab). Granul kering diuji sifat alirnya sedangkan tablet diuji sifat fisisnya meliputi keseragaman bobot, kekerasan, kerapuhan dan waktu hancur. Penggunaan variasi kombinasi pengering Avicel PH 101 dan Amprotab menghasilkan waktu alir yang baik sehingga keseragaman bobot memenuhi, kekerasan tablet baik, kerapuhan semakin rendah dan waktu hancur lebih lama. Kata kunci : mengkudu, Avicel PH 101, Amprotab, tablet, granulasi basah ABSTRACT It has been conducted a research on ethanol extract of Morinda citrifolia L tablet formulation. This research was aimed to find out whether composition variation of Avicel PH 101 and Amprotab as absorber could be formulated into tablet dosage form that meet requirement of good physical characteristic. The advantages of Avicel PH101 were having good compressibility and good the flow characteristic and fastening disintegration time of tablet. The advantage of Amprotab was cheap. Morinda citrifolia L. was extracted by maceration method by ethanol 70 %. Tablet of Morinda citrifolia L. was made by wet granulation. Ethanol extract of Morinda citrifolia L tablet was made in three formulas, they were formula I (100% Avicel PH 101), formula II (100% Amprotab) and formula II (50% Avicel PH 101: 50% Amprotab). Dry granule was examined the flow characteristics whereas tablets were examined the physical characteristic (weight uniformity, hardness, brittleness and disintegration time). Various combination of Avicel PH 101 and Amprotab resulted a good flowing time so that meet weight homogeneity, a good tablet hardness, lower brittleness and longer of disintegration time. Key word: Morinda citrifolia L., Avicel PH 101, Amprotab, tablet, wet granulation.References
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Published
2010-04-01
How to Cite
Nurkhayatun, G., Siswanto, A., & Hartanti, D. (2010). FORMULASI TABLET EKSTRAK ETANOL BUAH MENGKUDU (Morinda citrifolia L) DENGAN VARIASI AVICEL PH 101 DAN AMPROTAB SEBAGAI BAHAN PENGERING. PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 7(01). https://doi.org/10.30595/pji.v7i1.537
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