EFEK PENAMBAHAN POLIVINIL PIROLIDON TERHADAP DISOLUSI TABLET PARASETAMOL
DOI:
https://doi.org/10.30595/pji.v7i1.563Abstract
ABSTRAK Parasetamol merupakan obat yang mempunyai sifat agak sukar larut dalam air sehingga di tambahkan bahan pembasah untuk menurunkan sudut kontak agar mudah terbasahi. Tujuan penelitian ini untuk mengetahui pengaruh penambahan polivinil pirolidon terhadap sifat fisik dan disolusi tablet parasetamol. Dalam penelitian ini dibuat tiga formula tablet parasetamol dengan konsentrasi polivinil pirolidon yang berbeda (0,10%, 0,15%, 0,20%) sebagai bahan pembasah. Tablet dibuat dengan metode granulasi basah dan kemudian tablet diuji sifat fisiknya meliputi kekerasan, kerapuhan, waktu hancur. Diuji disolusinya dengan medium dapar fosfat pH 5,8. Hasil penelitian ini menunjukan bahwa penambahan polivinil pirolidon sebagai bahan pembasah berpengaruh terhadap sifat fisik tablet parasetamol. Semakin besar konsentrasi bahan pembasah, maka tablet semakin rapuh, kekerasannya semakin kecil, waktu hancurnya semakin cepat, persentase kadar terlarut pada menit ke-30 semakin tinggi. Dan yang memenuhi syarat farmakope adalah yang konsentrasinya 0,15% dan 0,20%. Kata kunci : polivinil pirolidon, bahan pembasah, tablet parasetamol ABSTRACT Paracetamol is kind of drug which is rather difficult to dissolve so it should be added water for its dissolving decrease relating for. The aim of this research were to know the effect of polyvinylpyrolidone addition. In this research four formula of paracetamol tablet were made by varied concentration of polyvinylpyrolidone (0.10%, 0.15%, 0.20%) as wetting agent. Paracetamol tablet were formulated by wet granulation method, and the tablet were tested its physical characteristics including the hardness, friability, disintegration time. Disolution rate were assaid by phosphate buffer medium at pH 5,8. The result of this research showed that addition of polyvinylpyrolidoneas wetting agent influenced on paracetamol tablet physical characteristics. The more concentration of wetting agent, the more friability, the less of hardness, the faster of disintegration time and the increasing of C30. and at concentration 0.15% and 0.20% are according to pharmacopea. Keywords : Polyvinylpyrolidone, wetting agent, paracetamol tabletReferences
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