Efficacy of Additional Vitamin D 1000 IU on Diabetic Neuropathy Peripheral for Sleep Quality, Moods, and Daily Activity
DOI:
https://doi.org/10.30595/pharmacy.v21i1.17199Keywords:
Brief Pain Inventory (BPI), Diabetic Neuropathy, vitamin D 1000 IUAbstract
Diabetic neuropathy is one of the most common long-term microvascular complications in diabetes mellitus, in which diabetic neuropathic pain is the most frequent symptom. Diabetic neuropathic pain mostly gets worse at night leading to sleep disturbances. Prolonged pain that does not improve can be stressful and decrease quality of life, symptomatic therapy has not been able to reduce the pain completely. This study aims to investigate the efficacy of additional therapy with 1000 IU of vitamin D on sleep quality, mood, and daily activity in patients with diabetic neuropathy. This study was a randomized controlled trial comparing the experimental group which was given symptomatic therapy and 1000 IU of vitamin D supplementary therapy and the control group which was only given symptomatic therapy, both of them were given 3 months of therapy and the pain impact was checked with the Brief Pain Inventory (BPI). Sampling was conducted in February 2021 using consecutive sampling through a computerized block randomization technique. Data analysis was conducted univariately, and bivariate used Mann-Whitney. Based on the Mann-Whitney test, it was found that the administration of 1000 IU of vitamin D to the experimental group showed a significantly superior improvement in sleep quality (p = 0.004), mood (p = 0.002), and daily activities (p =0.003) in the experimental group compared to the control group after 3 months intervention. Additional therapy of 1000 IU of vitamin D improves sleep quality, mood, and daily activity abilities in patients with diabetic neuropathic pain.
References
Alam U, Fawwad A, Shaheen F, Tahir B, Basit A, Malik RA, 2017. Improvement in neuropathy-specific quality of life in patients with diabetes after vitamin D supplementation. Journal of Diabetes Research, 2017, 7928083.
Alleman CJM, Westerhout KY, Hensen M, Chambers C, Stoker M, Long S, van Nooten FE, 2015. Humanistic and economic burden of painful diabetic peripheral neuropathy in Europe: A review of the literature. Diabetes Research and Clinical Practice, 109(2), 215-225.
Bahnasy WS, El-Heneedy YAE, El-Seidy EAS, Labib NAA, Ibrahim ISE, 2018. Sleep disturbances in diabetic peripheral neuropathy patients: A clinical and polysomnographic study. Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 54(1), 23.
Brod M, Pohlman B, Blum SI, Ramasamy A, Carson R. 2015. The burden of illness of diabetic peripheral neuropathic pain: A qualitative study. Patient 8, 339–348.
Esteghamati A, Fotouhi A, Faghihi-Kashani S, Hafezi-Nejad N, Heidari B, Sheikhbahaei S, Zandieh A, Nakhjavani M. 2016. Non-linear contribution of serum vitamin D to symptomatic diabetic neuropathy: A case-control study. Diabetes Research and Clinical Practice, 111, 44–50.
Fazelian S, Amani R, Paknahad Z, Kheiri SLK. 2019. Effect of vitamin D supplement on mood status and inflammation in vitamin D deficient type 2 diabetic women with anxiety: A randomized clinical trial. International Journal of Preventive Medicine, 10, 1–9.
Ghadiri-Anari A, Mozafari Z, Gholami S, Khodaei SA, Aboutorabi-zarchi M, Sepehri F, Nadjarzade A, Rahmanian M, Namiranian N. 2019. Dose vitamin D supplementations improve peripheral diabetic neuropathy? A before-after clinical trial. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13, 890–893.
Heidari N, Sajed, F, Mohammadi Y, Mirjalili M, Mehrpooya M. 2019. Ameliorative effects of n-acetylcysteine as adjunct therapy on symptoms of painful diabetic neuropathy. Journal of Pain Research, 12, 3147–3159.
Huiberts LM, Smolders KCHJ.,2021. Effects of vitamin D on mood and sleep in the healthy population: Interpretations from the serotonergic pathway. Sleep Medicine Reviews, 55, 101379.
Issa CM. 2017. Vitamin D and type 2 diabetes mellitus. Advances in Experimental Medicine and Biology, 996, 193–205.
Kaviani M, Nikooyeh B, Zand H, Yaghmaei P, Neyestani TR. 2020. Effects of vitamin D supplementation on depression and some involved neurotransmitters. Journal of Affective Disorders, 269, 28–35.
Khdour MR. 2020. Treatment of diabetic peripheral neuropathy: A review. Journal of Pharmacy and Pharmacology, 72(7), 863-872.
Majid MS, Ahmad HS, Bizhan H, Hosein HZM, Mohammad A. 2018. The effect of vitamin D supplement on the score and quality of sleep in 20–50-year-old people with sleep disorders compared with control group. Nutritional Neuroscience, 21, 511–519.
Meng LL, Liu Y, Geng RN, Tang YZ, Li DQ. 2016. Association of diabetic vascular complications with poor sleep complaints. Diabetology & Metabolic Syndrome, 8, 1–7.
Naranjo C, Ortega-Jiménez P, del Reguero L, Moratalla G, Failde I. 2020. Relationship between diabetic neuropathic pain and comorbidity. Their impact on pain intensity, diabetes complications and quality of life in patients with type-2 diabetes mellitus. Diabetes Research and Clinical Practice, 165, 108236.
Power D. 2020. Standards of medical care in diabetes: Response to position statement of the American Diabetes Association, Diabetes Care, 29(2), 476.
Shehab D, Al-Jarallah K, Abdella N, Mojiminiyi OA, Al Mohamedy H.,2015. Prospective evaluation of the effect of short-term oral vitamin D supplementation on peripheral neuropathy in type 2 diabetes mellitus. Medical Principles and Practice, 24, 250–256.
Soderstrom LH, Johnson SP, Diaz VA, Mainous AG. 2012. Association between vitamin D and diabetic neuropathy in a nationally representative sample: Results from 2001-2004 NHANES. Diabetic Medicine 29, 50–55.
Win MMTM, Fukai K, Nyunt HH, Hyodo Y, Linn KZ. 2019. Prevalence of peripheral neuropathy and its impact on activities of daily living in people with type 2 diabetes mellitus. Nursing and Health Sciences, 21, 445–453.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
