Perbaikan Gejala Neuropati Pada Pemberian Kombinasi Vitamin B Untuk Pasien Neuropati Diabetikum

Rizaldy Taslim Pinzon; Rosa De Lima Renita Sanyasi

doi:10.30595/pharmacy.v15i2.3482

Perbaikan Gejala Neuropati Pada Pemberian Kombinasi Vitamin B Untuk Pasien Neuropati Diabetikum

Rizaldy Taslim Pinzon, Rosa De Lima Renita Sanyasi

Abstract

Neuropati diabetikum (ND) adalah komplikasi utama yang sering muncul pada pasien diabetes mellitus (DM). Penelitian ini bertujuan untuk menilai efektivitas vitamin B kombinasi terhadap gejala klinis ND dan QoL (kualitas hidup/quality of life) pada pasien DM. Metode yang digunakan dalam penelitian ini adalah metode penelitian one group pre and post test design pada pasien DM dengan ND. Setiap subjek mendapatkan kombinasi vitamin B yang terdiri dari: vitamin B₁, vitamin B₆, dan vitamin B₁₂ dengan dosis masing-masing secara berurutan: 100 mg, 100 mg, 5000 mcg. Gejala klinis ND diukur dengan menggunakan Total Symptom Score (TSS). Angka QoL diukur dengan menggunakan kuesioner SF-8. Penilaian gejala dilakukan sebanyak 5 kali, dari penilaian awal hingga 3 bulan. Ada 104 subjek pada awal penelitian. Tujuh subjek tidak dapat mengikuti penelitian sampai selesai, sehingga tersisa 97 subjek pada akhir penelitian. Ada perbaikan gejala ND, yang meliputi sensasi nyeri tertusuk, sensasi nyeri terbakar, kesemutan, dan rasa kebas/baal, setelah pemberian kombinasi vitamin B. Perubahan tersebut bermakna secara statistik (p<0,0001). Hasil serupa juga tampak pada QoL. Ada perbaikan QoL dari awal penelitian hingga akhir penelitian. Perbedaan tersebut bermakna secara statistik (physical component summary dengan p<0,0001 dan mental component summary dengan p=0,0001). Kombinasi vitamin B efektif untuk memperbaiki gejala klinis dan meningkatkan kualitas hidup pada pasien ND.

Keywords

diabetes mellitus; neuropati diabetikum; SF-8; TSS; vitamin B kombinasi

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DOI: 10.30595/pharmacy.v15i2.3482

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ISSN: 2579-910X