Analisis LC-MS/MS Senyawa Metabolite Ekstrak Etanol daun Miana (Coleus scutellariodes (L) Benth) dan Potensinya sebagai Kandidat Obat Alzheimer
DOI:
https://doi.org/10.30595/pharmacy.v21i2.19662Keywords:
Alzheimer, Acetylcholinesterase, Miana, ScreeningAbstract
A secondary metabolic compound in plants is a bioactive substance connected to the chemical content of the plant, so some can be used as a medicine. Miana (Coleus Scutellariodes (L) Snapped) is a medicinal plant that has a potentially potent bioactive compound as an anticancer. Extraction of miana leaf with ethanol solvents held by an analysis of lc-ms, which shows some metabolite compounds contained in the miana. The method used is the extraction of miana leaves with ethanol, the study of compounds obtained from lc-ms, for the compound screening using Pchembl and ChemSpider websites and Pchembl's web server. The purpose of this research is to know and predict the potential of the associated bioactivity of the compounds found as candidates for new drugs. The results derived from this study are metabolite compounds found in the miana that are potentially Alzheimer drugs based on the screening done using Pchembl webservers based on a target protein acquired from extracting is acetylcholinesterase, which contains acetylcholinesterase as the target molecule that ACTS as an Alzheimer drugReferences
Azizah, M., Yanuar, A., & Firdayani, F. (2022). Dimensional Reduction of QSAR Features Using a Machine Learning Approach on the SARS-Cov-2 Inhibitor Database. Jurnal Penelitian Pendidikan IPA, 8(6), 3095–3101. https://doi.org/10.29303/jppipa.v8i6.2432
Boo, Y. C. (2021). Mechanistic basis and clinical evidence for the applications of nicotinamide (Niacinamide) to control skin aging and pigmentation. Antioxidants, 10(8). https://doi.org/10.3390/antiox10081315
Fathoni, M. M., Isnaeni, I., & Darmawati, A. (2021). Anti-bacterial activity of Rosela Flower Extract (Hibiscus sabdariffa L.) against Extended-Spectrum Beta-Lactamase (ESBL) Eschericia coli. Berkala Ilmiah Kimia Farmasi, 8(1), 7. https://doi.org/10.20473/bikfar.v8i1.31204
Fretes, C. De, Simaremare, E., Gunawan, E., & Farmasi, P. S. (2021). LC-MS Ekstrak Herba Anggrek Macan ( Grammatophyllum scriptum ( Lindl .)) Bl . serta Uji Aktivitas Sitotoksik Artikel Penelitian. 13, 165–173.
Mangurana, W. O. I., Yusnaini, Y., & Sahidin, S. (2019). ANALISIS LC-MS/MS (Liquid Crhomatogaph Mass Spectrometry) DAN METABOLIT SEKUNDER SERTA POTENSI ANTIBAKTERI EKSTRAK n-HEKSANA SPONS Callyspongia aerizusa YANG DIAMBIL PADA KONDISI TUTUPAN TERUMBU KARANG YANG BERBEDA DI PERAIRAN TELUK STARING. Jurnal Biologi Tropis, 19(2), 131–141. https://doi.org/10.29303/jbt.v19i2.1126
Moss, D. E. (2020). Improving anti-neurodegenerative benefits of acetylcholinesterase inhibitors in alzheimer’s disease: Are irreversible inhibitors the future? International Journal of Molecular Sciences, 21(10). https://doi.org/10.3390/ijms21103438
Olivier, M. T., Muganza, F. M., Shai, L. J., & Gololo, S. S. (2016). In vitro antigonorrhea activity of the aerial part of asparagus suaveolens n-hexane fraction and palmitone as a bioactive compound. Natural Product Communications, 11(9), 1319–1321. https://doi.org/10.1177/1934578x1601100935
Ratih, G. A. M., Imawati, M. F., Purwanti, D. I., Nugroho, R. R., Wongso, S., Prajogo, B., & Indrayanto, G. (2019). Metabolite profiling of justicia gendarussa herbal drug preparations. Natural Product Communications, 14(6), 1–5. https://doi.org/10.1177/1934578X19856252
Ratu, A. P., Setyahadi, S., & Simanjuntak, P. (2017). AKTIVITAS FRAKSI etanol daun sirsak (Annona muricata Linn.) SEBAGAI PENGHAMBATasetilkolINesterase. Parapemikir : Jurnal Ilmiah Farmasi, 6(2), 145–150. https://doi.org/10.30591/pjif.v6i2.586
Ubaedilah, N. A., & Supriyatna, A. (2023). Analisis dan Penerapan Manfaat Kandungan Senyawa Daun Miana (Coleus scutellarioides (L.) Benth.) di Kiaracondong, Kota Bandung. Hippocampus: Jurnal Pengabdian Kepada Masyarakat, 2(1), 75–82. https://doi.org/10.47767/hippocampus.v2i1.547
Yanti, A., Mursiti, S., Widiarti, N., Nurcahyo, B., & Alauhdin, M. (2019). Optimalisasi Metode Penentuan Kadar Etanol dan Metanol pada Minuman Keras Oplosan Menggunakan Kromatografi Gas ( KG ). Indonesian Journal of Chemical Science, 8(1), 54–59. http://journal.unnes.ac.id/sju/index.php/ijcs%0AOptimalisasi
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