The effect of the combination of ethanolic extracts of bael leaves (Aegle marmelos) and brown algae (Padina australis) on HDL levels in Rattus norvegicus fed a high-fat diet
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Background: High-density lipoprotein (HDL) is a component of plasma cholesterol that plays an essential role in preventing lipid imbalances in the plasma. Â Aegle marmelos contain aegeline and Padina australis contains fucoxanthin, which can potentially increase HDL. However, no studies have reported the combined effect of Aegle marmelos and Padina australis on raising HDL levels.
Purpose: This study aimed to determine the effect of a combination of ethanolic extracts of Aegle marmelos and Padina australis on HDL levels in Rattus norvegicus fed a high-fat diet.
Methods: This experimental research used a post-test only control group design, conducted in 30 Rattus norvegicus that were randomly allocated into five groups: K(-) group of normal diet, K(+) high-fat diet, KPI high-fat diet and atorvastatin 1,5 mg/kg BW/day, KPII high-fat diet and extract of 60 mg/kg BW/day, KPIII high-fat diet and extract of 240 mg/kg BW/day.
Results: The HDL levels of K (-), K (+), KPI, KPII, and KPIII were 64.75 mg/dl, 68.50 mg/dl, 61.60 mg/dl, 66.75 mg/dl, and 67.00 mg/dl, respectively. The one-way ANOVA test showed F = 0.148, p = 0.929.
Conclusion: The combination of ethanolic extracts of Aegle marmelos and Padina australis leaves at 60 mg/kg BW/day and 240 mg/kg BW/day for 30 days could increase serum HDL levels in rats fed with HFD higher than atorvastatin, but the results were not statistically significant.1. Kesehatan K, Penelitian B, Kesehatan P. HASIL UTAMA RISKESDAS 2018.; 2018.
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